Hereditary peripheral neuropathy is a genetic condition that affects the nerves outside the brain and spinal cord. Unlike neuropathies with unknown causes, this type is inherited—passed down through family lines.
The most well-known form is Charcot-Marie-Tooth disease (CMT), but there are many subtypes, each affecting the nerves differently. These conditions may damage the motor nerves (controlling movement), sensory nerves (controlling sensation), or both, leading to symptoms like weakness, tingling, and pain, especially in the hands and feet.
Some individuals have hereditary motor sensory neuropathy (HMSN), while others may experience hereditary sensory and autonomic neuropathy (HSAN), which can also disrupt functions like digestion or blood pressure control.
What Causes Hereditary Peripheral Neuropathy?
These neuropathies are caused by mutations in specific genes responsible for nerve structure and function. When those genes malfunction, the protective covering around nerves (myelin) or the nerve fibers themselves (axons) deteriorate, leading to impaired signal transmission.
Some common inherited neuropathies include:
Charcot-Marie-Tooth Disease (CMT) – The most prevalent form
Hereditary Sensory and Autonomic Neuropathy (HSAN)
Hereditary Neuropathy with Liability to Pressure Palsies (HNPP)
Diagnosis often involves genetic testing, nerve conduction studies, and family history analysis.
Common Signs & Symptoms of Hereditary Peripheral Neuropathy
Symptoms often begin subtly but can progress over time. The most common signs include:
Gradual muscle weakness in legs, feet, hands, or arms
Difficulty walking or frequent tripping
High arches or flat feet (a common physical sign of CMT)
Numbness or tingling in the extremities
Loss of coordination or balance
Muscle wasting in the lower legs or hands
Autonomic symptoms in HSAN, such as blood pressure instability, bladder issues, or impaired sweating
Even within the same family, symptoms can vary widely, making early recognition and personalized care essential.
The key risk factor for hereditary peripheral neuropathy is a family history of nerve-related disorders. Other considerations include:
While you can't change your genetics, you can change how you support your nerves—and that's where Nupera can help.
You may not be able to change your genes, but you can take steps to manage your symptoms and protect your nerves.
This noninvasive approach helps restore nerve health—naturally and effectively.
Experience lasting relief from peripheral neuropathy with Nupera's innovative 2-step treatment that promotes nerve healing and regeneration.
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